GeneWeb -
Consanguinity

This part
explains the concepts of "consanguinity" and "relationship" used by GeneWeb and how they are computed.

Consanguinity and Relationship
The genom of
an individual consists of a great number of genes which, if mutations are
ignored, reproduce identically. The genes can be used to measure the identity of
a person.

The genes are placed in precise locations named "locus". Each individual has
for each locus two genes, one transmitted by his mother, the other by his
father, and transmits to his children a copy of the one of his genes.

The Consanguinity of an individual x is the probability
cg(x) to find in a given locus two identical genes.

The Relationship of two individuals x and y is the
probability pr(x, y) to find in the same locus two identical genes.

Computations
A probability calculus shows
that:

The consanguinity cg(x) is equal to the relationship
pr(px,mx) of the parents px and mx of
x.

If x..a..y is a minimal relationship link between x and
y (i.e. such as the branches x..a and a..y have
just a in common), then it contributes to the relationship of
x and y of a factor:
1
---- (1 + cg a)
n+1
2

where n is the length (distance x..a + distance
a..y) of the relationship link x..a..y.

The relationship of x and y is the sum of the
contributions of all their minimal relationship links.

GeneWeb
GeneWeb displays the consanguinity and the
relationship in the form of a percentage.

Statistically, on the great number of locuses of an individual, the
consanguinity corresponds approximately to the percentage of his locuses holding
identical genes.

The algorithms of consanguinity and relationship were written by Didier Rémy,
director of research at INRIA. We thank him for that.

References

Albert Jacquard. Genetic structures of the Populations. Masson
& Co, 1970.

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